Two chlorinated lincomycin analogues tested in this host-parasite system cured blood-induced infections.
The chloroquine- resistant Oak Knoll strain of Plasmodium falciparum, recently adapted to the owl monkey (Aotus trivirgatus), was insusceptible to chloroquine therapy. The efficacy of U-21 and U-24 is of particular interest since they represent major structural departures from compounds commonly used in the treatment of malaria.Īctivity of Two Chlorinated Lincomycin Analogues Against Chloroquine- Resistant Falciparum Malaria in Owl Monkeys1 The speed of clearance of parasites was not dose-related, but curative activity appeared dependent upon the amount of drug given as well as the number of daily treatments. These lincomycin analogues cleared trophozoites from the peripheral blood by the end of the 7-day treatment period. Acute infections were treated orally for 7 consecutive days with either 15 or 75 mg of clindamycin hydrochloride (U-21) per kg per day, 10 or 50 mg of N-demethyl-4'-pentyl clindamycin hydrochloride (U-24) per kg per day, or 20 mg of chloroquine base per kg per day. The efficiency of irradiation in inducing lincomycin resistant adventitious shoots and kiloploid nature of chloroplast genome is discussedĪctivity of two chlorinated lincomycin analogues against chloroquine- resistant falciparum malaria in owl monkeys. Radiation treatment was efficient in inducing a high frequency of lincomcyn resistant shoots developing on cotyledon explants whereas EMS failed to induce antibiotic resistant shoots. Mutagenised were explants were implanted on shoot regeneration medium containing 100 mg 1 −1 limcomycin. International Nuclear Information System (INIS)Ĭotyledon explants from axenic cultures of Solanum melongena were exposed to 1KR gamma rays and 0.1% ethylmethane sulphonate (EMS). Induction and selection of lincomycin-resistant plants in Solanum melongena Also 50.0% of MRSA strains were sensitive to the liposomalny form of lincomycin that shows the perspective for the development of the liposomal forms of antibiotics to cure staphylococcal infections. aureus strains to the liposomal form of lincomycin in comparison with usual lincomycin.
Antibacterial activity of the liposomal form of lincomycin is studied concerning the patients selected from the different biotopes with pyo inflammatory diseases of staphylococcus strains (15 strains – methicillin sensitive, 12 strains - methicillin resistant.It is shown authentically the higher sensitivity of S. Determination of the minimum inhibiting concentration was carried out by a tablet micromethod by consecutive cultivations of the samples under study.It is shown that MIC of liposomal lincomycin is eight times as low as usual lincomycin (0,23mkg/ml to 1,87 mkg/ml.
N., the Candidate of Сhemical Sciences.The purpose of this research work was to study liposomal inhibiting concentration of the liposomalny form of lincomycin and a commercial preparation lincomycin (produced by CJSC “Pharmaceutical firm "Darnitsa". This work studies antistaphylococcal activity (according to MIC of the liposomal form of lincomycin developed in the Institute of Dermatology and Venereology of Ukraine by Ivanova N. One of the ways to improve antibacterial preparations still remains the development of their liposomal forms. The complexity of antibiotic therapy of diseases caused by methicillin resistant staphylococci having high poly resistance almost to every classes of antibacterial agents is of prime importance. ANTISTAPHYLOCOCCAL ACTIVITY OF LIPOSOMAL FORMS OF LINCOMYCINĭirectory of Open Access Journals (Sweden)įull Text Available Nowadays the vital problem of modern medicine is a tendency to emerging of both nosocomial and community-acquired strains before antibiotic resistance forming.
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